Incorporating background frequency improves entropy-based residue conservation measures |
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Authors: | Kai Wang and Ram Samudrala |
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Institution: | (1) Computational Genomics Group, Department of Microbiology, University of Washington, Washington, USA |
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Abstract: | Background Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments.
High scoring amino acid positions may correlate with structurally or functionally important residues. However, amino acid
background frequencies are usually not taken into account in these entropy-based scoring schemes. |
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