Genomic approaches to investigate the pathogenicity of Cryptococcus neoformans |
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Authors: | Thomas G. Mitchell |
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Affiliation: | (1) Department of Molecular Genetics and Microbiology, Duke University Medical Center, Box 3803, Room 214, Jones Building, Research Drive, Durham, NC 27710, USA |
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Abstract: | Cryptococcus neoformans, a model pathogenic fungus, exemplifies the application of several genome-wide approaches to investigate fungal pathogenicity. This review focuses on the application of genome-wide approaches to large populations of clinical and environmental isolates rather than to a small number of well-defined laboratory strains. Specific examples include the construction and utilization of genetic linkage maps, analyses of quantitative trait genes and loci, and the use of genome-wide genetic markers in population studies. |
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