Immunocytochemical demonstration of retinal S-antigen in the pineal organ of four mammalian species |
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| Authors: | Dr. Horst-W. Korf Morten Møller Igal Gery J. Samuel Zigler David C. Klein |
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| Affiliation: | (1) Department of Anatomy and Cytobiology, Justus-Liebig-University of Giessen, Giessen, Germany;(2) Institute of Medical Anatomy, Department B, The University of Copenhagen, Copenhagen, Denmark;(3) Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA;(4) Section of Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA;(5) Institut für Anatomie und Zytobiologie, Justus-Liebig-Universität Giessen, Aulweg 123, D-6300 Giessen, Germany |
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| Abstract: | By means of immunocytochemistry retinal S-antigen is selectively demonstrated in retinal photoreceptor cells of the rat and in pinealocytes of the hedgehog, rat, gerbil and cat. Brain areas surrounding the pineal organ are immunonegative. The immunoreactive material is evenly distributed in the perikarya of the cells. Occasionally, inner segments of retinal photoreceptors and processes of pinealocytes are also stained. The outer segments of retinal photoreceptors display a strong immunoreaction. In both pinealocytes and retinal photoreceptors the intensity of the immunoreaction varied considerably among individual cells. The immunocytochemical demonstration of retinal S-antigen in mammalian pinealocytes indicates that these cells still bear characteristics of photoreceptors. This finding is in accord with the concept that mammalian pinealocytes are derived from pineal photoreceptor cells of poikilothermic vertebrates. |
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| Keywords: | Pineal organ (mammals) Retinal S-antigen Photoreceptors Retina Immunocytochemistry |
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