Reduced-folate carrier (RFC) is expressed in placenta and yolk sac,as well as in cells of the developing forebrain,hindbrain, neural tube,craniofacial region,eye, limb buds and heart |
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| Authors: | Dennis?M?Maddox,Anna?Manlapat,Penny?Roon,Puttur?Prasad,Vadivel?Ganapathy,Sylvia?B?Smith author-information" > author-information__contact u-icon-before" > mailto:sbsmith@mail.mcg.edu" title=" sbsmith@mail.mcg.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | (1) Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, USA;(2) Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, USA;(3) Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, USA;(4) Department of Ophthalmology, Medical College of Georgia, Augusta, USA |
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| Abstract: | Background Folate is essential for cellular proliferation and tissue regeneration. As mammalian cells cannot synthesize folates de novo, tightly regulated cellular uptake processes have evolved to sustain sufficient levels of intracellular tetrahydrofolate cofactors to support biosynthesis of purines, pyrimidines, and some amino acids (serine, methionine). Though reduced-folate carrier (RFC) is one of the major proteins mediating folate transport, knowledge of the developmental expression of RFC is lacking. We utilized in situ hybridization and immunolocalization to determine the developmental distribution of RFC message and protein, respectively. |
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