Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation

Authors:	Daniela?Boassa,Andrea?J?Yool author-information" > author-information__contact u-icon-before" > mailto:ayool@u.arizona.edu" title=" ayool@u.arizona.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Program in Neuroscience, University of Arizona, Tucson, Arizona 85724-5051, USA;(2) Dept. of Physiology, University of Arizona College of Medicine, Tucson, Arizona, USA;(3) Dept. of Pharmacology, University of Arizona College of Medicine, Tucson, Arizona, USA

Abstract:	Background Aquaporin-1 (AQP1) functions as an osmotic water channel and a gated cation channel. Activation of the AQP1 ion conductance by intracellular cGMP was hypothesized to involve the carboxyl (C-) terminus, based on amino acid sequence alignments with cyclic-nucleotide-gated channels and cGMP-selective phosphodiesterases.

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