Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm |
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| Authors: | Youjun Hu Ann-Leslie Zaslav Neetu Radhakrishnan Marc Golightly Colette Pameijer |
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| Affiliation: | 1Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794 USA ;2Hematology & Oncology, Department of Internal Medicine, Stony Brook University Hospital, Stony Brook, NY 11794 USA ;3Department of Surgery, Stony Brook University Hospital, Stony Brook, NY 11794 USA |
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| Abstract: | A case of primary myelofibrosis involving lymph node and with a novel cytogenetic abnormality [del (18) (p11.2-3)] is reported. The abnormalities are identical among specimens from the lymph node, peripheral blood, and bone marrow that were analyzed years apart. Additionally, we show that the infiltrate by dysplastic megakaryocytes in the lymph node morphologically mimics a metastatic mesenchymal neoplasm, even when the clinical history myelofibrosis was known. |
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| Keywords: | Megakaryocyte Myelofibrosis Immunohistochemical stain Cytogenetics |
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