| 海洋来源放线菌3275化学成分及抗肿瘤活性研究 |
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| 引用本文： | 赵文英,朱天骄,古静燕,顾谦群,朱伟明.海洋来源放线菌3275化学成分及抗肿瘤活性研究[J].天然产物研究与开发,2006,18(3):405-407,417. |
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| 作者姓名： | 赵文英 朱天骄 古静燕 顾谦群 朱伟明 |
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| 作者单位： | 中国海洋大学海洋药物教育部重点实验室,山东省海洋药物重点实验室,青岛,266003;青岛科技大学化工学院,青岛,266042 |
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| 基金项目： | 国家高技术研究发展计划(863计划);国家高技术研究发展计划(863计划);山东省青岛市 |
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| 摘 要： | 从海洋来源的放线菌Streptomyces sp．3275中分到7个化合物，经IR，ESI-MS，NMR等光谱数据鉴定及与文献对照，确定其结构为环（脯-缬）（1），环（脯-酪）（2），环（脯-甘）（3），环（脯-异亮）（4），环（脯-亮）（5），胆甾醇（6）及1-甲基-1，2，3，4．四氢咔啉-3-羧酸（7）；并采用SRB法对其抗肿瘤活性进行了测试，其中化合物2，3，5对温敏型小鼠乳腺癌细胞tsFT210显示弱的增殖抑制活性。
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| 关 键 词： | 海洋来源放线菌 链霉菌 次级代谢产物 抗肿瘤活性 |
| 文章编号： | 1001-6880（2006）03-0405-04 |
| 收稿时间： | 2005-09-16 |
| 修稿时间： | 2005-09-162006-02-20 |
Studies on the Chemical Constituents and Antitumor Activity of Secondary Metabolites of Marine-derived Streptomyces sp. 3275 |
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| ZHAO Wen-ying,Zhu Tian-jiao,GU Jing-yan,GU Qian-qun,ZHU Wei-ming.Studies on the Chemical Constituents and Antitumor Activity of Secondary Metabolites of Marine-derived Streptomyces sp. 3275[J].Natural Product Research and Development,2006,18(3):405-407,417. |
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| Authors: | ZHAO Wen-ying Zhu Tian-jiao GU Jing-yan GU Qian-qun ZHU Wei-ming |
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| Abstract: | In order to find bioactive compounds, the secondary metabolites of the fermentation of actinomycete streptomyces sp.3275 were studied,Among seven compounds were isolated from the active extract by repeated chromatography over silica gel,sephadex LH-20 column and HPLC. Their structures were identified on the basic of comparison to literature and spectroscopic analysis as cyclo (Val-Pro) (1), cylco (Pro-Tyr) (2), cyclo (Gly-Pro) (3), cyclo (Pro-Ile) (4), cyclo (Leu-Pro) (5),cholest-5-en-3β-ol (6), 1-methyl- 1,2,3,4-tetrahydro-carboline-3-carboxylic acid (7). Compounds 2,3,5 exhibited weak cytotoxicities against tsFT210 cell line. |
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| Keywords: | marine-derived actinomycete Streptomyces sp secondary metabolites antitumor activity |
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