A three-locus model for the chicken major histocompatibility complex |
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Authors: | J R L Pink W Droege K Hála V C Miggiano A Ziegler |
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Institution: | (1) Basel Institute for Immunology, Grenzacherstra\e 487, Postfach 4005, Basel 5, Switzerland;(2) Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Flemingovo nám. 2, Praha, Czechoslovakia;(3) Present address: Deutsches Krebsforschungszentrum, Im Neuenheimerfeld 280, Postfach 101949, D-6900 Heidelberg, Germany;(4) Present address: MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH Cambridge, England |
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Abstract: | The major histocompatibility complexes (B complexes) of chickens of various origins have been studied by serological and biochemical methods. TwoB complexes are of particular interest:B
R1, a recombinant haplotype derived from theB complexes of the inbred CB and CC strains, andB
G-B1
, theB haplotype of the G-B1 strain. TheB
R1 haplotype differs detectably from theB
CB haplotype only at a locus controlling the synthesis of an antigen, B-G, which (in peripheral blood) is present only on red cells. Anti-B-G sera precipitate, from125I-labeled red cell lysates, two chains of apparent molecular weights 42,000 and 31,000 (measured under reducing conditions); the smaller is perhaps derived by proteolysis from the larger. TheB
G-B1 haplotype differs detectably from theB
CC haplotype only at a locus controlling the synthesis of an antigen whose tissue distribution and biochemical and biological properties are identical to those of B-G. The chicken major histocompatibility complex therefore contains at least three loci—those controlling synthesis of the B-G, and of the previously defined B and B-L antigens.The following abbreviations are used in this paper MHC
major histocompatibility complex
- SDS-PAGE
sodium dodecyl sulfate polyacrylamide gel electrophoresis
- MLR
mixed leukocyte reaction
- GVH
graft-versus-host reaction |
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Keywords: | |
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