Toxic effect of troglitazone on cultured rat hepatocytes |
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| Authors: | Toyoda Y Tsuchida A Iwami E Miwa I |
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| Affiliation: | Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan. |
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| Abstract: | We examined the cytotoxicity of troglitazone toward cultured rat hepatocytes. The drug concentration- and time-dependently decreased cell viability and increased lactate dehydrogenase leakage from the cells. Troglitazone-induced cell death was characterized by "DNA ladders", condensation of nuclei, and a positive reaction to in situ nick-end labeling. The results indicate that troglitazone can cause apoptotic cell death in cultured rat hepatocytes. |
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