Prognostic Significance of High VEGF-C Expression for Patients with Breast Cancer: An Update Meta Analysis |
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| Authors: | Zhiqiao Zhang Guanying Luo Hongfeng Tang Canchang Cheng Peng Wang |
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| Institution: | 1Department of Infectious Disease, The First People’s Hospital of Shunde, Shunde, Guangdong, China;2Department of Internal Medicine, The Chencun Affiliated Hospital of First People’s Hospital of Shunde, Shunde, Guangdong, China;3Department of Science and Education, The First People’s Hospital of Shunde, Shunde, Guangdong, China;University of North Carolina at Chapel Hill School of Medicine, UNITED STATES |
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| Abstract: | BackgroundThe prognostic significance of vascular endothelial growth factor C (VEGF-C) expression in breast cancer (BC) patients remains controversial. Therefore, this meta-analysis was performed to determine the prognostic significance of VEGF-C expression in BC patients.ResultsThe present meta analysis totally included 21 eligible studies and 2828 patients with BC. The combined HRs were 1.87(95% CI 1.25–2.79, P = 0.001) for DFS and 1.96(95% CI 1.15–3.31, P = 0.001) for OS. The pooled HRs of non-Asian subgroup were 2.04(95%CI 1.36–3.05, P = 0.001) for DFS and 2.61(95%CI 1.51–4.52, P = 0.001) for OS, which were significantly higher than that of Asian subgroup. The funnel plot for publication bias was symmetrical. The further Egger''s test and Begg''s test did not detect significant publication bias (all P>0.05).ConclusionsThe present meta analysis strongly supported the prognostic role of VEGF-C expression for DFS and OS in BC patients, especially for patients in non-Asian countries. Furthermore, stratification by VEGF-C expression may help to optimize the treatments and the integrated managements for BC patients. |
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