A mathematical model relating diffusion of hydrophobic ions to their adsorption on biological membranes as detected with a microdialyzer |
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Authors: | Piero Fariselli Salvatore Di Bernardo Rita Casadio |
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Affiliation: | (1) Laboratory of Biophysics, Department of Biology, University of Bologna, Italy |
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Abstract: | We analyze the diffusion of hydrophobic molecules in a dialysis apparatus with respect to their adsorption on biological membrane vesicles confined to one dialysis chamber. The process is described with a kinetic model, which shows that, depending on the pattern of the adsorption isotherm, the kinetic parameter of the diffusion process through the dialysis membrane is up to two-fold increased by the presence of the adsorbing vesicle surface. The model successfully describes the diffusion of tetraphenylborate and 9-aminoacridine in the presence of chromatophores from photosynthetic membrane, with which they interact with hyperbolic and S-shaped isotherms, respectively. |
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Keywords: | Microdialaysis adsorption isotherms biological membranes tetraphenylboron 9-aminoacridine mathematical model |
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