Phosphorylation by protein kinase C modulates agonist binding to striatal dopamine D2 receptors |
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| Authors: | P Rogue J Zwiller A N Malviya G Vincendon |
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| Institution: | Centre de Neurochimie du C.N.R.S., Strasbourg, France. |
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| Abstract: | The effect of purified protein kinase C (PKC) on dopamine D2 receptor binding was studied. Saturation binding with 3H]spiperone was not affected. In competition experiments using agonists PKC-treated membranes showed a significant reduction in the proportion of high affinity sites, and the influence of GTP gamma S was abolished. These results suggest that PKC-dependent mechanisms can regulate the coupling between the dopamine D2 receptor and its G-protein. |
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