吐温80 在深部脏器肿瘤热化疗中的应用研究

目的：研究热增敏剂吐温80在深部肿瘤热化疗中的临床应用疗效。方法：采用吐温80合并热化疗综合治疗晚期肿瘤118例，并与同时期未采用吐温80的热化疗组98例进行比较。膀胱癌复发5例，伴腹水、腹膜转移7例。小剂量化疗用5-FU、丝裂霉素、顺铂等行膀胱灌注或腹腔注射，吐温80浓度为0．2％。肿瘤射频热疗机，f：41MHz。平均随访时间36个月。结果：复发性膀胱癌完全缓解率达60％，血尿消失，3例在12～34月随访期间膀胱镜检查未复发；伴腹水者完全缓解率达85．7％（CR6／7），中位生存期8．5月，腹痛、腹胀、便血等消失。治疗未引起恶心、呕吐等明显的消化道症状，肝、肾和骨髓功能损害。结论：在肿瘤的热化疗中。合用吐温80不仅可以降低化疗药物的剂量，而且降低热疗时的温度，减少毒副作用，改善症状和体征。

The Initial Application of Tween 80 in Thermochemotherapy of Deep Seated Tumors

ABSTRCT Objective: To observe the thermal sensitization effect of Tween 80.Methods: 12 patients with advanced stage malignant tumors were given thermochemotherapy(TCT) combined with Tween 80.Five of them were bladder cancer and 7 had intraperitoneal metastases with malignant ascites.After irrigation of bladder and intraperitoneal injection with solution containing small amount 5-FU and mitomycin and cisplatin,local thermotherapy with RF heating machine(f:41MHz)were carried out,Tween 80 was added into the solution with final concentration of 0.2%.Results: For recurred bladder cancer,complete remission rate(CRR) was 60% with disappeared hemourine and 12-34 months of follow-up revealed no recurrence in 3 cases.For peritoneal metastases,CRR was 85.7%of patients with a median survival of 8.5 months,abdominal pain and distension and bloody stool disapeared.No obvious nausea,vomiting,liver,renal and myeloid functional lesion were observed during the treatment.Conclusions: In TCT of malignant tumors,combination of Tween 80 can not only reduce the dosage of chemical drugs but also lower the therapeutic temperature and toxicity.