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The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma |
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| Authors: | Gu Zhaodi Mitsui Hidetoshi Inomata Kenichi Honda Masako Endo Chiaki Sakurada Akira Sato Masami Okada Yoshinori Kondo Takashi Horii Akira |
| Affiliation: | a Department of Molecular Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan b Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan c Division of Thoracic Surgery, Miyagi Cancer Center Hospital, 47-1 Medeshima-Shiote-aza Nodayama, Natori, 981-1293, Japan |
| Abstract: | FBXW7 is reported to be a tumor suppressor gene, and the functional inactivation of FBXW7 has been reported in various human tumors. In this study, we investigated the FBXW7 gene in human thymoma; although no mutations were evident, a significantly high frequency of methylation in the FBXW7 β-form promoter was observed in types B1 or higher (P = 0.014). We propose a novel mechanism for the pathogenesis of thymoma by FBXW7 β-form and hypothesize that expressional suppression plays an important role in the malignant potential of thymoma. |
| Keywords: | Methylation FBXW7 β-form Thymoma |
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