Epigallocatechin gallate promotes GLUT4 translocation in skeletal muscle |
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Authors: | Ueda Manabu Nishiumi Shin Nagayasu Hironobu Fukuda Itsuko Yoshida Ken-ichi Ashida Hitoshi |
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Affiliation: | a Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan b Research Center for Food Safety and Security, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan |
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Abstract: | In this study, we investigated whether epigallocatechin gallate (EGCg) affects glucose uptake activity and the translocation of insulin-sensitive glucose transporter (GLUT) 4 in skeletal muscle. A single oral administration of EGCg at 75 mg/kg body weight promoted GLUT4 translocation in skeletal muscle of rats. EGCg significantly increased glucose uptake accompanying GLUT4 translocation in L6 myotubes at 1 nM. The translocation of GLUT4 was also observed both in skeletal muscle of mice and rats ex vivo and in insulin-resistant L6 myotubes. Wortmannin, an inhibitor of phosphatidylinositol 3′-kinase, inhibited both EGCg- and insulin-increased glucose uptakes, while genistein, an inhibitor of tyrosine kinase, failed to inhibit the EGCg-increased uptake. Therefore, EGCg may improve hyperglycemia by promoting GLUT4 translocation in skeletal muscle with partially different mechanism from insulin. |
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Keywords: | Epigallocatechin gallate Tea Glucose transporter Insulin resistance Muscle |
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