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Induction of fatty acid-binding protein 3 in brown adipose tissue correlates with increased demand for adaptive thermogenesis in rodents |
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| Authors: | Yamashita Hitoshi Wang Zuocheng Wang Youxue Segawa Masahiko Kusudo Tatsuya Kontani Yasuhide |
| Institution: | a Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan b Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta., Canada T6G 2H7 c Department of Surgery, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA d Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa 359-8513, Japan e Department of Food Science for Health, Minami-Kyushu University, Miyazaki 880-0032, Japan |
| Abstract: | We investigated the contribution of fatty acid-binding protein 3 (FABP3) to adaptive thermogenesis in brown adipose tissue (BAT) in rodents. The expression of FABP3 mRNA in BAT was regulated discriminatively in response to alteration of the ambient temperature, which regulation was similar and reciprocal to the regulation of uncoupling protein 1 (UCP1) and leptin, respectively. FABP3 expression in the BAT was significantly higher in the UCP1-knockout (KO) mice than in the wild-type ones, and these KO mice showed a higher clearance rate of free fatty acid from the plasma. In addition, FABP3 expression in the BAT was increased greatly with the development of diet-induced obesity in mice. These results indicate that the induction of FABP3 in BAT correlates with an increased demand for adaptive thermogenesis in rodents. FABP3 appears to be essential for accelerating fatty acid flux and its oxidation through UCP1 activity for non-shivering thermogenesis in BAT. |
| Keywords: | Adaptive thermogenesis Brown adipose tissue Fatty acid-binding protein 3 Uncoupling protein 1 Gene expression Knockout mouse |
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