Functional adaptation to oxidative stress by memory T cells: an analysis of the role in the cardiovascular disease process |
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Authors: | Elahi Maqsood M Matata Bashir M |
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Affiliation: | a Wessex Cardiothoracic Centre, BUPA Hospital, Southampton, UK b Liverpool Heart & Chest Hospital NHS Trust, Thomas Drive, Liverpool L14 3PE, UK |
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Abstract: | T cells participate in combating infection and critically determine the outcomes in any given disease process. Impaired immune response occurs in a number disease processes such as in cancer and atherosclerosis although the underlying mechanisms are still not fully understood. This article gives an up-to-date review of T cells development and functional adaptation to pathophysiological stimuli and participation in the cardiovascular disease process. In addition, we have discussed the signaling pathways controlled by the microenvironment that determine T cells function and resultant type of immune response. We have also discussed in detail how oxidative stress is a key component of the micro environmental interaction. |
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Keywords: | Regulatory T cells Oxidative stress Memory T cells Coronary heart disease T helper subsets |
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