Ultrastructural studies of endocrine-like cells in the fundic gastric mucosa of the bullfrog,Rana catesbeiana |
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Authors: | Fabián Michelangeli Dalia M. Sulcas Marie-Christine Ruiz |
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Affiliation: | (1) Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela;(2) IVIC-CBB, P.O. Box 21827, 1020-A Caracas, Venezuela |
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Abstract: | Summary This study is concerned with electron-microscopic observations on endocrine or paracrine cells in the fundic gastric mucosa of the bullfrog. Also, an attempt was made to identify the histamine-releasing cells involved in the secretagogue response. At least three distinct endocrine-like cell types were found. The classification is based on the appearance of secretory granules and other organelles, and the relationship of endocrine-like cells with other cells in the tissue. The amphibian endocrine-like cells resemble the ECL, D and EC cells of mammals. Type-I (ECL) cells showed degranulation after repeated stimulation with tetragastrin (TG), acetylcholine (ACh) and K+ depolarizing solution, all of which release histamine. |
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Keywords: | Gastric endocrine or paracrine cells Histamine-releasing cell Acid secretion Amphibian |
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