Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice |
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| Authors: | Kang Myung-Soo Soni Vishal Bronson Roderick Kieff Elliott |
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| Institution: | Channing Laboratory and Infectious Diseases Division, Department of Medicine and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA. |
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| Abstract: | To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice. |
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