Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo |
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Authors: | Yu Kuo-Long Wang Xiangdong Alan Civiello Rita L Trehan Ashok K Pearce Bradley C Yin Zhiwei Combrink Keith D Gulgeze H Belgin Zhang Yi Kadow Kathleen F Cianci Christopher W Clarke Junius Genovesi Eugene V Medina Ivette Lamb Lucinda Wyde Philip R Krystal Mark Meanwell Nicholas A |
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Affiliation: | Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5, Research Parkway, Wallingford, CT 06492, USA. |
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Abstract: | The introduction of acidic and basic functionality into the side chains of respiratory syncytial virus (RSV) fusion inhibitors was examined in an effort to identify compounds suitable for evaluation in vivo in the cotton rat model of RSV infection following administration as a small particle aerosol. The acidic compounds 2r, 2u, 2v, 2w, 2z, and 2aj demonstrated potent antiviral activity in cell culture and exhibited efficacy in the cotton rat comparable to ribavirin. In a BALB/c mouse model, the oxadiazolone 2aj reduced virus titers following subcutaneous dosing, whilst the ester 2az and amide 2aab exhibited efficacy following oral administration. These results established the potential of this class of RSV fusion inhibitors to interfere with infection in vivo following topical or systemic administration. |
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