Synthesis and biological activity of dialkylphosphocholines |
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| Authors: | Milo&#x Luk
, Martin Mrva, Eva Fischer-Fodor, Ivan Lacko, Mari n Bukovský , Natalia Mikl &#x ov , Franti&#x ek Ondriska,Ferdinand Deví nsky |
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| Affiliation: | Miloš Lukáč, Martin Mrva, Eva Fischer-Fodor, Ivan Lacko, Marián Bukovský, Natalia Miklášová, František Ondriska,Ferdinand Devínsky |
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| Abstract: | A series of dialkylphosphocholines were prepared and evaluated for their biological activity. The antiprotozoal activity was determined against Acanthamoeba lugdunensis. Compound 15 exhibited excellent trophocidal activity. None of the tested dialkylphosphocholines exhibited better fungicidal activity against Candida albicans than miltefosine. The antineoplastic activity was determined against HeLa. The most cytotoxic was compound 10, which was more active against tumor cells as against normal cells. |
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| Keywords: | Acanthamoeba lugdunensis Candida albicans Cytotoxic activity Dialkylphosphocholines Miltefosine |
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