Allele distribution at the HVR-IgH hypervariable locus in unrelated individuals living in the Ural,Siberia, and northern Kazakhstan |
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Authors: | Bin'ko I A Shorokhova D A Shvarts Iu B Demakov S A Novoselov V P |
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Institution: | Regional Forensic Bureau, Novosibirsk, 630087 Russia. |
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Abstract: | Allelic polymorphism at a hypervariable locus mapped to the 5'-region of the gene cluster encoding JH segments of human immunoglobulin heavy chain H (IgH-VNTR) was typed in 462 unrelated individuals living in the Urals, Siberia, and Northern Kazakhstan. Molecular characteristics of the three previously unknown IgH-VNTR alleles is presented. The observed genotype frequencies were concordant with those expected under the Hardy-Weinberg distribution. The data obtained can be used in the work of regional forensic laboratories. |
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