Reaction of FeBlm with DNA: Fe(II)Blm-NO. |
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| Authors: | W E Antholine D H Petering |
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| Affiliation: | 1. Radiation Biology and Biophysics Section, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, U.S.A.;2. Laboratory for Molecular Biomedical Research, Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, U.S.A. |
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| Abstract: | The structure of the iron bleomycin nitric oxide complex is altered in the presence of calf thymus DNA as determined from epr studies. This altered structure predominates for one iron bleomycin nitric oxide molecule per coil of the DNA helix. In the absence of nitric oxide, as the pH is lowered, iron bleomycin dissociates in two steps, supporting the hypothesis that in-plane nitrogens may be easily perturbed. |
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| Keywords: | epr electron paramagnetic resonance Blm bleomycin FeBlm iron bleomycin iron bleomycin nitric oxide complex IHP inositol hexaphosphate |
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