| Abstract: | A study was made of the rate of the transfer of phospholipids and cholesterol between 14C-microsomes and mitochondria of gamma-irradiated rat liver. Cytosole and cell organelles of nonirradiated and irradiated rat liver were combined to reveal the increase in the cholesterol-transfer activity of liver cell cytosole 60 min following irradiation (12 Gy). Roughly purified lipid-transfer proteins from liver cytosole of control rats transported lipids, at an equal rate, between organelles isolated from liver cells of control and exposed rats. Radiation modification of cell organelle membranes was only detected upon the reaction with cytosole from the irradiated rat liver. |
