Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins |
| |
Authors: | Lin Deng Yuanyuan Lu Xiaodi Zhao Yi Sun Yongquan Shi Hongwei Fan Changhao Liu Jinfeng Zhou Yongzhan Nie Kaichun Wu Daiming Fan Xuegang Guo |
| |
Institution: | 1. State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, Shaanxi 710032, China;2. Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710038, China |
| |
Abstract: | Ran, a member of the Ras GTPase family, has important roles in nucleocytoplasmic transport. Herein, we detected Ran expression in pancreatic cancer and explored its potential role on tumour progression. Overexpressed Ran in pancreatic cancer tissues was found highly correlated with the histological grade. Downregulation of Ran led to significant suppression of cell proliferation, cell cycle arrest at the G1/S phase and induction of apoptosis. In vivo studies also validated that result. Further studies revealed that those effects were at least partly mediated by the downregulation of Cyclin A, Cyclin D1, Cyclin E, CDK2, CDK4, phospho-Rb and Survivin proteins and up regulation of cleaved Caspase-3. |
| |
Keywords: | Ran Proliferation Pancreatic cancer Cell cycle Survivin |
本文献已被 ScienceDirect 等数据库收录! |
|