High chondroitin sulfate proteoglycan 4 expression correlates with poor outcome in patients with breast cancer |
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Authors: | Nicholas C Hsu Pei-Yung Nien Kazunari K Yokoyama Pei-Yi Chu Ming-Feng Hou |
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Institution: | 1. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;2. Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;3. Department of Pathology, St. Martin De Porres Hospital, Chiayi, Taiwan;4. School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan;5. Division of General and Gastroenterological Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;6. Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan |
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Abstract: | Chondroitin sulfate proteoglycan 4 (CSPG4), a transmembrane proteoglycan originally identified in melanoma cells, has been reported to be expressed in breast cancer cells. This study was performed to examine the expression and significance of CSPG4 in a cohort of breast cancer patients. Immunohistochemical analysis of CSPG4 was performed on tissue microarrays constructed from tissue specimens from 240 breast cancer patients. CSPG4 staining was correlated with clinical and pathological characteristics, overall survival (OS), and disease recurrence. Contradicting to a previous report, our results showed that high CSPG4 expression was not related to triple-negative status of breast cancer patients. The Kaplan–Meier method showed that high CSPG4 expression was significantly associated with shorter time to recurrence (TTR). Patients with high CSPG4 expression had poorer OS and shorter TTR in a multivariate survival analysis after adjustment for stage, tumor grade, expression of estrogen receptor and progesterone receptor, and HER2 overexpression. This study showed that high CSPG4 expression correlates with disease recurrence and OS in breast cancers. |
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Keywords: | Chondroitin sulfate proteoglycan Triple-negative breast cancer Survival Recurrence |
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