Extracellular lipid metabolism influences the survival of ovarian cancer cells |
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| Authors: | Shohei Kuwata Kei Ohkubo Shun Kumamoto Naoto Yamaguchi Naoki Izuka Kaeko Murota Toshifumi Tsujiuchi Masao Iwamori Nobuyuki Fukushima |
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| Institution: | 1. Division of Molecular Neurobiology, Department of Life Science, School of Science and Engineering, Kinki University, Higashiosaka, Japan;2. Division of Food and Nutritional Chemistry, Department of Life Science, School of Science and Engineering, Kinki University, Higashiosaka, Japan;3. Division of Cancer Biology and Bioinformatics, Department of Life Science, School of Science and Engineering, Kinki University, Higashiosaka, Japan;4. Division of Biochemistry, Department of Life Science, School of Science and Engineering, Kinki University, Higashiosaka, Japan |
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| Abstract: | Lysophosphatidic acid (LPA) is an extracellular lipid mediator consisting of a fatty acid and a phosphate group linked to the glycerol backbone. Here, we show that 1-oleoyl- and 1-palmitoyl-LPA, but not 1-stearoyl- or alkyl-LPA, enhance HNOA ovarian cancer cell survival. Other lysophospholipids with oleic or lauric acid, but not stearic acid, also induce the survival effects. HNOA cells have the lipase activities that cleave LPA to generate fatty acid. Oleic acid stimulates HNOA cell survival via increased glucose utilization. Our findings suggest that extracellular lysolipid metabolism might play an important role in HNOA cell growth. |
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| Keywords: | Lysophosphatidic acid Fatty acid Lysophospholipase Ovarian cancer cell Cell survival |
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