TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress |
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| Authors: | Olaf Maier Roman Fischer Cristina Agresti Klaus Pfizenmaier |
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| Affiliation: | 1. Institute of Cell Biology and Immunology, Stuttgart University, Allmandring 31, 70569 Stuttgart, Germany;2. Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy |
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| Abstract: | The neuroprotective role of TNF receptor 2 (TNFR2) has been shown in various studies. However, a direct role of TNFR2 in oligodendrocyte function has not yet been demonstrated. Using primary oligodendrocytes of transgenic mice expressing human TNFR2, we show here that TNFR2 is primarily expressed on oligodendrocyte progenitor cells. Interestingly, preconditioning with a TNFR2 agonist protects these cells from oxidative stress, presumably by increasing the gene expression of distinct anti-apoptotic and detoxifying proteins, thereby providing a potential mechanism for the neuroprotective role of TNFR2 in oligodendrocyte progenitor cells. |
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| Keywords: | CNP, 2&prime ,3&prime -cyclic nucleotide 3&prime -phosphodiesterase CNS, central nervous system EAE, experimental autoimmune encephalomyelitis MBP, myelin basic protein MS, multiple sclerosis OLG, oligodendrocyte OPC, oligodendrocyte progenitor cell PLL, poly-l-lysine PLP, proteolipid protein scTNFR2, single chain TNF specific for TNFR2 SOD, superoxide dismutase TNC, tenascin C TNF, tumor necrosis factor TNFR, tumor necrosis factor receptor TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling |
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