The interplay between epigenetic silencing,oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells |
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| Authors: | Ewelina Swiderek Wojciech Kalas Edyta Wysokinska Alicja Pawlak Janusz Rak Leon Strzadala |
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| Affiliation: | 1. Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland;2. Montreal Children’s Hospital Research Institute, McGill University, QC, Canada |
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| Abstract: | Bcl-2/adenovirus E1B-19 kDa-interacting protein 3 (BNIP3) is an important mediator of cell survival and a member of the Bcl-2 family of proteins that regulate programmed cell death and autophagy. We have previously established a link between the expression of oncogenic HRas and up-regulation of BNIP3 and the control of autophagy in cancer cells. However, in view of varied expression of BNIP3 in different tumor types and emerging uncertainties as to the role of epigenetic silencing, oncogenic regulation and the role of BNIP3 in cancer are still poorly understood. |
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| Keywords: | 5-Aza-2&prime -deoxycytidine BNIP3 Colorectal cancer HIF-1 Hypoxia KRas |
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