The BAG2 protein stabilises PINK1 by decreasing its ubiquitination |
| |
| Authors: | Xiangqian Che Beisha Tang Xuejing Wang Dong Chen Xinxiang Yan Hong Jiang Lu Shen Qian Xu Guanghui Wang Jifeng Guo |
| |
| Affiliation: | 1. The Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People’s Republic of China;2. State Key Laboratory of Medical Genetics, Changsha 410008, Hunan, People’s Republic of China;3. Neurodegenerative Disorders Research Center, Central South University, Changsha 410008, Hunan, People’s Republic of China;4. Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha 410008, Hunan, People’s Republic of China;5. Laboratory of Molecular Neuropathology, Department of Pharmacology, Soochow University College of Pharmaceutical Sciences, Suzhou, Jiangsu 201203, China |
| |
| Abstract: | Mutations in the PTEN-induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). Thus far, little is known about what can regulate the ubiquitin proteasome pathway of PINK1. Here, we report BAG2 (Bcl-2-associated athanogene family protein 2), a member of the BAG family, which directly binds with and stabilises PINK1 by decreasing its ubiquitination. Moreover, we found that BAG2 also binds with the pathogenic R492X PINK1 mutation directly and more tightly. Moreover, BAG2 stabilises the R492X PINK1 mutation by decreasing its ubiquitination to a greater extent than the wild-type species. Our data correlate BAG2 to PINK1 for the first time, strengthening the important role of BAG2 in PD-related neurodegeneration. |
| |
| Keywords: | PD, Parkinson disease PINK1, mutations in PTEN-induced kinase 1 UPS, ubiquitin proteasome system BAG, Bcl-2associated athanogene BAG2, Bcl-2-associated athanogene 2 DMEM, Dulbecco&rsquo s modified Eagle&rsquo s medium |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
