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The nucleotide sequence of the gene encoding the K99 subunit of enterotoxigenic Escherichia coli |
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| Authors: | Bert Roosendaal Wim Gaastra Frits K de Graaf |
| Institution: | Department of Microbiology, Biological Laboratory, Vrije Universiteit, de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands;Department of Microbiology, The Technical University of Denmark, Building 221, DK - 2800 Lyngby-Copenhagen, Denmark |
| Abstract: | Abstract The nucleotide sequence of the gene encoding the K99 fimbrial subunit of enterotoxigenic Escherichia coli was determined. It appeared that the subunit is composed of 159 amino acid residues preceded by a N-terminal signal sequence of 22 amino acid residues. The secondary structure of the mature K99 polypeptide and the location of potential antigenic determinants were predicted. A comparison was made between the amino acid sequence of the K99 subunit and the subunits of other fimbrial adhesins. |
| Keywords: | Adhesion fimbriae nucleotide sequence |
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