High-Resolution Genetic Map of the Human Glutamyl Aminopeptidase Gene (ENPEP) |
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| Authors: | Li Li Qi Wu Barry L Barnoski Max D Cooper |
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| Institution: | aDivision of Developmental and Clinical Immunology, Department of Microbiology, Pediatrics and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35294;dDepartment of Microbiology, Pediatrics and Medicine, University of Alabama at Birmingham, Howard Hughes Medical Institute, Birmingham, Alabama, 35294;bDepartment of Microbiology, Pediatrics and Medicine, University of Alabama at Birmingham, Southern Biotechnology Associates, Inc. Birmingham, Alabama, 35294;cDivision of Human Genetics and Molecular Biology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104 |
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| Abstract: | The murine B-lymphocyte differentiation antigen BP-1/6C3 has been identified as glutamyl aminopeptidase (EAP), the gene symbol for which isENPEP.Using genomic DNA encoding for human EAP as a probe, we identified theENPEPgene location on human chromosome 4q25 by polymerase chain reaction analysis of a human/rodent somatic cell hybrid mapping panel and by fluorescencein situhybridization. Using a radiation hybrid panel, the gene order aroundENPEPwas determined to be centromere–D4S1236–(570 kb)–ENPEP–(210 kb)–D4S262–(270 kb)–D4S953–(270 kb)–D4S474–(570 kb)–IF. The linkage ofENPEPto complement factor I (IF) confirms the human chromosome band 4q25 localization predicted from the chromosomal location of murineENPEP.HumanENPEPthus provides an additional marker for the long arm of chromosome 4 that should facilitate studies of this genomic region. |
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