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Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold |
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| Authors: | Vaccaro Wayne D Sher Rosy Berlin Michael Shih Neng-Yang Aslanian Robert Schwerdt John H McCormick Kevin D Piwinski John J West Robert E Anthes John C Williams Shirley M Wu Ren-Long She H Susan Rivelli Maria A Mutter Jennifer C Corboz Michel R Hey John A Favreau Leonard |
| Affiliation: | The Schering Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA. |
| Abstract: | We report the discovery of novel histamine H(3) receptor antagonists based on 4-[(1H-imidazol-4-yl)methyl]piperidine. The most potent compounds in the series (e.g., 7) result from the attachment of a substituted aniline amide to the main pharmacophore piperidine via a two-methylene linker. |
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