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Indazole derivatives as novel bradykinin B1 receptor antagonists |
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| Authors: | Bodmer-Narkevitch Vera Anthony Neville J Cofre Victoria Jolly Samson M Murphy Kathy L Ransom Richard W Reiss Duane R Tang Cuyue Prueksaritanont Thomayant Pettibone Douglas J Bock Mark G Kuduk Scott D |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. vbodmer@mac.com |
| Abstract: | A new class of indazole-derived bradykinin B(1) antagonists and their structure-activity relationships (SAR) is reported. A number of compounds were found to have low-nanomolar affinity for the human B(1) receptor and possess acceptable P-gp and pharmacokinetics properties. |
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