Atropine depresses release of neurotensin and its effect on the exocrine pancreas |
| |
Authors: | G.E. Feurle I. Baca W. Knauf |
| |
Affiliation: | Medizinische Poliklinik, Chirurgische Klinik, University of Heidelberg, D-6900 Heidelberg, Federal Republic of Germany |
| |
Abstract: | In this study the effect of 10 and 20 μg · kg?1 · h?1 atropine sulfate on release and pancreatic effects of neurotensin was studied in 4 dogs. Neurotensin plasma levels rose significantly when a liquid fat preparation was infused intraduodenally. This rise was almost completely abolished by simultaneous infusion of atropine. Atropine further suppressed basal and fat-stimulated output of pancreatic volume, protein, and bicarbonate; it also reduced pancreatic secretion stimulated by an intravenous infusion of low doses (2.5 to 20 pmol · kg?1 · min?1) neurotensin. The effect of higher doses (80 and 240 pmol · kg?1 · min?1) of neurotensin was less affected.As neurotensin plasma levels in contrast to normal oral feeding did not rise after sham feeding, our findings suggest that release and action of neurotensin may at least in part be dependent on a cholinergic, non-cephalic mechanism. |
| |
Keywords: | exocrine pancreatic secretion gastrointestinal hormones sham feeding cholinergic mechanism |
本文献已被 ScienceDirect 等数据库收录! |