三氧化二砷栓塞联合肝动脉介入治疗转移性肝癌的疗效并33例临床观察

目的：观察并探讨三氧化二砷碘油栓塞联合置管介入化疗治疗转移性肝癌的临床效果。方法：选取辽宁省肿瘤医院介入治疗科2008-2010年收治的转移性肝癌患者33例，进行肝动脉造影及间接门脉造影，根据肝动脉造影或门脉造影结果，根据肝动脉供血情况分别采取肝动脉化疗栓塞及肝动脉灌注化疗方法治疗，3．4周为1治疗周期，共完成4个治疗周期，治疗结束后评价患者，陆床有效率，随访半年、1年、2年患者生存率。结果：①介入治疗后，患者，临床症状均改善，KPS得分明显高于化疗前（P〈0．05），临床总有效率81．82％。②随访半年、1年、2年生存率分别为90．9l％、66．67％、33.33％，肝动脉化疗栓塞组患者中远期生存率明显高于肝动脉灌注化疗的患者。结论：三氧化二砷可从多角度抑制癌细胞，临床应用安全有效；对于不能手术和不适宜手术的转移性肝癌患者，根据肝动脉供血情况和特点选择合适的介入治疗，可获得满意疗效。

Arsenic Trioxide Embolization Combined with Hepatic Artery Interventional Therapy for Metastatic Liver Cancer and 33 Cases Study

Objective： The paper is to observe and explore clinical efficacy of arsenic trioxide embolization combined with hepatic artery interventional therapy in treatment of metastatic liver cancer. Methods： 33 metastatic liver cancer patients from 2010 to 2012 of Liaoning Province Tumor Hospital were chosen as study objects, of which hepatic artery angiography and indirect portal vein angiography were performed, according to results of hepatic artery angiography or portal vein angiography, treatment of arsenic trioxide embolism chemotherapy of hepatic artery and hepatic arterial infusion chemotherapy were taken, 3-4 weeks for one therapeutic cycle, after total completion of 4 treatment cycles, clinical efficiency was noted and compared between 2 kinds of Interventional therapies, and survival rate for half a year, 1 years, 2 years was followed after treatment. Results： ①After interventional treatment, clinical symptoms of patients were all improved, KPS score was significantly higher than that ofpre-treatment （P〈0.05）, and total clinical efficiency rate was 81.82%.②Patients＇ survival rates for 6 months, 1 year, 2 year were 90.91%, 66.67%, 33.33% respectively, hepatic artery embolism chemotherapy patients with higher long-term survival rate than patients conducted hepatic arterial infusion chemotherapy. Conclusion： Arsenic trioxide can inhibit cancer cell from multiple perspectives, whose clinical application is effective. For metastatic liver cancer patients who were not suitable for operation, proper hepatic artery interventional therapy should be selected based on hepatic artery blood supply and other characteristics, which will get satisfactory curative effect.