冻融胚胎移植中三种不同内膜准备方法的妊娠结局比较

目的：比较三种不同内膜准备方法中复苏胚胎移植的妊娠结局。方法：对因女方输卵管因素不孕的248个冻融囊胚移植周期的临床资料进行回顾性分析。将内膜准备方法分为自然周期组、全激素替代周期组和半激素替代周期组三种，分别对各组的着床率、临床妊娠率、生化妊娠率和早期流产率进行分析比较。结果：自然周期组的子宫内膜厚度显著高于全激素周期组和半激素替代周期组（P〈0．05），差异有统计学意义。而这三组病人在年龄、不孕年限和移植胚胎数目上则均无明显差异（P〉0．05）。另外，三种内膜准备方法的着床率、临床妊娠率、早期流产率及生化妊娠流产率亦无显著性差异（P〉O．05）。结论：冻融胚胎移植中，对于排卵正常患者我们建议采用自然周期法更为经济、方便。而对于月经周期不正常，排卵障碍的病人应依实际情况采用全激素周期或半激素周期方案。

Comparison of the Effect of Three Different Endometrial Preparation Methods on the Pregnancy Outcome

Objective： To investigate the effect of three different endometrial preparation methods on the pregnancy outcome of frozen-thawed embryo transfer （FET）. Methods： 248 FET cycles those factors of infertility due to the woman＇s fallopian tubes were retro- spectively analyzed and divided into three groups： natural cycle group, completely hormone replacement treatment cycle and partial hor- one replacement treatment cycle group. The implantation rate, clinical pregnancy, biochemical pregnancy abortion rate and early abortion rate were compared between these three different groups. Results： The natural cycle endometrial thickness group was significantly higher than the completely hormone replacement treatment cycle and partial hormone replacement treatment cycle group （P〈0.05）. The differ- nce was statistically significant. There were no significant differences among the nature cycle group, completely hormone replacement treatment cycle and partial hormone replacement treatment cycle group on the age, duration of infertility and the number of embryos transferred （P〉0.05）. The difference was not statistically significant. The FET cycle outcomes were similar during the nature cycle group, completely hormone replacement treatment cycle and partial hormone replacement treatment cycle group on the implantation rate, clini- cal pregnancy rate, biochemical pregnancy abortion rate and early abortion rate. There were no significant differences among them （P〉0. 05）. The difference was not statistically significant. Conclusions： It is proposed that the patients who have normal ovulation to adopt the nomal natural cycle method that were more economical and convenient. The patients who have ovulation disorders should be in accor- dance with the actual situation of the completely hormone replacement treatment cycle or the partial hormone replacement treatment cycle. The doctors choose the best treatment plan should be based on the actual situation of the patients.