Quantitative Proteomics Links the Intermediate Filament Nestin to Resistance to Targeted BRAF Inhibition in Melanoma Cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Quantitative Proteomics Links the Intermediate Filament Nestin to Resistance to Targeted BRAF Inhibition in Melanoma Cells

Institution:	From the 3Proteome Center Tuebingen, Interfaculty Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany;;4Center for Dermatooncology, Department of Dermatology, University of Tuebingen, Tuebingen, Germany

Abstract:	Download : Download high-res image (124KB) Download : Download full-size image Highlights ?Quantitative phosphoproteome of BRAF drug-resistance in melanoma cells. ?Cytoskeletal proteins are downregulated in resistant vs. sensitive cells. ?Nestin is associated with an invasive phenotype and resistance to MEK and BRAF inhibitors. ?Nestin depletion affects PI3K/AKT and integrin signaling similar to resistant cells.

Keywords:	Melanoma Drug resistance Mass Spectrometry SILAC Phosphoproteome Cytoskeletal proteins Nestin Quantitative proteomics Signaling pathways Skin cancer
本文献已被 ScienceDirect 等数据库收录！