Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation |
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| Institution: | Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University,Changsha 410078, China;Child Health Institute of New Jersey, Department of Neuroscience, Rutgers Robert Wood Johnson Medical School,New Brunswick, NJ 08901, USA;Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University,Changsha 410078, China;Psychiatry Department, SUNY Upstate Medical University, Syracuse, NY 13210, USA;Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University,Changsha 410078, China;Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100101, China;Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University,Changsha 410078, China;Affiliated Hospital of Guilin Medical University, Guilin 541000, China;Psychiatry Department, SUNY Upstate Medical University, Syracuse, NY 13210, USA;Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University,Changsha 410078, China;National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410000, China |
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| Abstract: | Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To decode the molecular framework of these diseases, many studies use human postmortem brain samples. These studies reveal brain-specific genetic and epigenetic patterns via high-throughput sequencing technologies. Identifying best practices for the collection of postmortem brain samples, analyzing such large amounts of sequencing data, and interpreting these results are critical to advance neuropsychiatry. We provide an overview of human brain banks worldwide, including progress in China, highlighting some well-known projects using human postmortem brain samples to understand molecular regulation in both normal brains and those with neuropsychiatric disorders. Finally, we discuss future research strategies, as well as state-of-the-art statistical and experimental methods that are drawn upon brain bank resources to improve our understanding of the agents of neuropsychiatric disorders. |
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| Keywords: | Neuropsychiatric disorders Brain bank Postmortem brain Expression quantitative trait loci GWAS interpretation |
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