An Advanced Strategy for Comprehensive Profiling of ADP-ribosylation Sites Using Mass Spectrometry-based Proteomics*
Institution:
3. Proteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Abstract:
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Highlights
?Comparing proteolytic digestions and precursor fragmentation methods for MS of ADPr
?Identification of 11,265 unique ADPr-modified peptides
?Mapping of hundreds of peptides co-modified by phosphorylation and ADPr
?ADPr modification of specific residue types displays spatial preferences
