Tailoring of microbes for the production of high value plant-derived compounds: From pathway engineering to fermentative production |
| |
| Institution: | 1. Rajiv Gandhi Centre for Biotechnology, Trivandrum 695 014, India;2. Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR- NIIST), Trivandrum 695 019, India;3. Department of Civil and Environmental Engineering, Yonsei University, Seoul, South Korea;4. Center for Innovation and Translational Research, CSIR- Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226 001, India;1. Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India;2. Homi Bhabha National Institute, Mumbai 400094, India;1. Department of Biotechnology, Panjab University, Chandigarh 160014, India;2. Department of Microbiology and Cell Biology, Indian Institute Of Science, Bangalore, Karnataka 560012, India;3. National Institute of Malaria Research, Dwarka, New Delhi, Delhi 110077, India |
| |
| Abstract: | Plant natural products have been an attracting platform for the isolation of various active drugs and other bioactives. However large-scale extraction of these compounds is affected by the difficulty in mass cultivation of these plants and absence of strategies for successful extraction. Even though, synthesis by chemical method is an alternative method; it is less efficient as their chemical structure is highly complex which involve enantio-selectivity. Thus an alternate bio-system for heterologous production of plant natural products using microbes has emerged. Advent of various omics, synthetic and metabolic engineering strategies revolutionised the field of heterologous plant metabolite production. In this context, various engineering methods taken to synthesise plant natural products are described with an additional focus to fermentation strategies. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
