Multi-isotype Glycoproteomic Characterization of Serum Antibody Heavy Chains Reveals Isotype- and Subclass-Specific N-Glycosylation Profiles期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Multi-isotype Glycoproteomic Characterization of Serum Antibody Heavy Chains Reveals Isotype- and Subclass-Specific N-Glycosylation Profiles

Affiliation:	3. From the 3Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts;;4. Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts

Abstract:	Download : Download high-res image (148KB) Download : Download full-size image Highlights •nLC-MS/MS method to analyze immunoglobulin (Ig) N-glycopeptides from human serum. •Multi-isotype, site-specific characterization of immunoglobulin N-glycosylation. •IgA2 sequence and glycosylation-site variant analyses. •Platform to define disease-specific N-glycan signatures for different Ig isotypes.

Keywords:	Antibodies* N-Glycosylation Glycoproteomics Serum/Plasma* Immunology* Immunoglobulin G1 (IgG1) Immunoglobulin G4 (IgG4) Immunoglobulin M (IgM) Immunoglobulins A1 and A2 (IgA1 and IgA2) sequence variant
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