Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*

Affiliation:	From the 3Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, Ghent, Belgium;;4Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium;;5Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle-upon-Tyne, UK;;6Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Center for Infection and Immunity of Lille, Lille, France

Abstract:	Download : Download high-res image (115KB) Download : Download full-size image Highlights •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs. •Label-free quantification determined 2843 phagosomal proteins. •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells. •Increased recruitment of antigen cross-presentation molecules to these phagosomes.

Keywords:	Label-free quantification Cellular organelles* Inflammatory response Protein Identification* Endocytosis* Cell biology* Immunology* dendritic cell phagocytosis phagosome maturation
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