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Metabolic Cross-talk Between Human Bronchial Epithelial Cells and Internalized Staphylococcus aureus as a Driver for Infection*
Affiliation:3. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany;;4. Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;;5. Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany;;6. Division of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Groningen, The Netherlands
Abstract:
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  • Highlights
    • ?Interplay of epithelial cells and internalized S. aureus was dissected over 96 h.
    • ?Surviving host cells contain nonreplicating bacteria that persists in the cytoplasm.
    • ?Competition over resources triggers temporal metabolic changes.
    • ?Metabolic adaptation of host and bacteria determines the outcome of infection.
    Keywords:Energy metabolism  Infectious disease  Apoptosis*  Autophagy  Bacteria  Host-Pathogen Interaction  bronchial epithelial cells  in vivo proteomics  persister  population heterogeneity  Staphylococcus aureus
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