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microRNA-222 Attenuates Mitochondrial Dysfunction During Transmissible Gastroenteritis Virus Infection
Institution:3. From the 3College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China;;4. 4Huyi District Center for Animal Disease Control and Prevention, Xi''an, Shaanxi 710300, P.R. China.
Abstract:
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  • Highlights
    • •microRNA-222 attenuates TGEV-induced mitochondrial dysfunction.
    • •microRNA-222 downregulates THBS1 and CD47.
    • •THBS1 is the target of microRNA-222 during TGEV infection.
    • •THBS1 and CD47 increase mitochondrial Ca2+ level and reduced mitochondrial membrane potential (MMP).
    Keywords:Tandem Mass Spectrometry  Viruses  Mitochondria Function or Biology  Molecular Biology  HPLC  Pathway Analysis  Cluster of Differentiation 47 (CD47)  microRNA-222  Proteomics  Thrombospondin-1 (THBS1)  Transmissible Gastroenteritis Virus
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