Cheiroarthropathy: A Common Disorder in Patients in the T1D Exchange |
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| Institution: | 1. Northwestern University Feinberg School of Medicine, Chicago, Illinois;2. Jaeb Center for Health Research, Tampa, Florida;3. Children''s Mercy Hospital, Kansas City, Missouri;4. University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania;5. Washington University School of Medicine, St. Louis, Missouri.;1. From the National Heart, Lung, and Blood Institute, Bethesda, Maryland;2. University of Miami, Coral Gables, Florida;3. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland;4. Albert Einstein College of Medicine at the Yeshiva University, Bronx, New York;5. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;6. University of Puerto Rico Graduate School of Public Health, Department of Biostatistics and Epidemiology, San Juan, Puerto Rico;7. Northwestern University, Fienberg School of Medicine, Chicago, Illinois;8. Institute for Behavioral and Community Health, Graduate School of Public Health, San Diego State University, Chula Vista, California.;1. Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO;2. Department of Nephrology, University of Colorado Denver, Aurora, CO;3. Barbara Davis Center for Diabetes, University of Colorado Denver, Aurora, CO;4. Benaroya Research Institute, Seattle, WA;5. Jaeb Center for Health Research Inc., Tampa, FL;6. Department of Nephrology, University of Toronto School of Medicine, Toronto, ON;7. Department of Pediatrics, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA;1. From the Department of Endocrinology, Albany Medical Center, Albany, New York.;1. Department of Anesthesia and Intensive Care, Cochin University Hospital, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France |
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| Abstract: | Objective: Diabetic cheiroarthropathy is a long-term complication of diabetes that causes significant morbidity and can impair functional abilities. It has not been well studied in individuals with type 1 diabetes (T1D). The T1D Exchange registry provided an opportunity to assess the frequency of cheiroarthropathy and related characteristics.Methods: An internet-based survey was sent to 6,199 registry participants ≥18 years old, with 1,911 (31%) responding (62% female, 90% non-Hispanic White, mean age 40 years, median diabetes duration 20 years, mean glycated hemoglobin [HbA1c] 7.7% [61 mmol/mol]).Results: A total of 586 (31%) adults reported a diagnosis of ≥1 upper extremity disorder: 293 (15%) reported frozen shoulder, 293 (15%) trigger finger, 261 (14%) carpal tunnel, and 92 (5%) Dupuytren contracture, with 281 (15%) reporting ≥2 disorders. Those with upper extremity joint disorders were more likely older (P<.001) and had longer duration of diabetes (P<.001) than those without. HbA1c levels at the time of survey completion were 7.6% in participants with cheiroarthropathy versus 7.8% (62 mmol/mol) in participants without cheiroarthropathy.Conclusion: Cheiroarthropathy is common in adults with T1D. Additional research is needed to understand the pathogenesis and risk factors for this disorder. Standards of care for early recognition and treatment of diabetic cheiroarthropathy are also needed, particularly for adults with long-term diabetes. Improved awareness of cheiroarthropathy signs and symptoms of is needed so that patients can be identified and seek treatment before the condition causes disability.Abbreviations: BMI = body mass index; CGM = continuous glucose monitor; DCCT/EDIC = Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications; HbA1C = glycated hemoglobin; T1D = type 1 diabetes; T2D = type 2 diabetes |
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