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Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver
Affiliation:1. Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA;2. Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA;3. Center for Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, TX, USA;4. Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA;5. Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA;6. Children’s Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX, USA;7. Department of Clinical Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA;8. Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA;9. Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA;10. Sate Key Laboratory of Genetic Engineering, School of Life Sciences, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, Shanghai 200438, China
Abstract:
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  • Keywords:pyruvate carboxylase  metabolic flux  anaplerosis  TCA cycle  urea cycle  gluconeogenesis  liver physiology  high-fat diet  oxidative stress
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