Cross-linking Proteomics Indicates Effects of Simvastatin on the TLR2 Interactome and Reveals ACTR1A as a Novel Regulator of the TLR2 Signal Cascade期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Cross-linking Proteomics Indicates Effects of Simvastatin on the TLR2 Interactome and Reveals ACTR1A as a Novel Regulator of the TLR2 Signal Cascade

Institution:	3. 3Department of Chemistry and Biochemistry, University of Texas at Arlington, Texas 76019;4. 4Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709

Abstract:	Download : Download high-res image (107KB) Download : Download full-size image Highlights •An innovative co-IP crosslinking proteomics study was designed for the TLR2 interactome. •Proteomic profiling revealed combinatorial effects of simvastatin and Pam3CSK4 on the TLR2 interactome. •ACTR1A and MARCKSL1 proteins were identified as potential interactors of TLR2 during the immune response. •ACTR1A has important modulatory actions on the TLR2 pro-inflammatory signaling cascade.

Keywords:	Affinity proteomics Protein Cross-linking Mass Spectrometry Protein-Protein Interactions Immunoaffinity Alpha centractin Immunoprecipitation Pam3CSK4 simvastatin TLR2
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