Multidimensional Proteomics Identifies Declines in Protein Homeostasis and Mitochondria as Early Signals for Normal Aging and Age-associated Disease in Drosophila,期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Multidimensional Proteomics Identifies Declines in Protein Homeostasis and Mitochondria as Early Signals for Normal Aging and Age-associated Disease in Drosophila,

Affiliation:	3. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, Shanghai, 201210, China;4. University of Chinese Academy of Sciences, Beijing, 100049, China

Abstract:	Download : Download high-res image (77KB) Download : Download full-size image Highlights •Proteomic landscapes of Drosophila somatic and reproductive tissues during aging. •Pulsed metabolic labeling determines a decline in protein synthesis with age. •Drosophila model of human Parkinson's disease signifies an early-onset decline in protein synthesis. •Collapse of proteostasis and mitochondria are early signals for normal aging.

Keywords:	aging Drosophila melanogaster quantification protein synthesis mitochondria function or biology proteome homeostasis
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