A Robust and Versatile Automated Glycoanalytical Technology for Serum Antibodies and Acute Phase Proteins: Ovarian Cancer Case Study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A Robust and Versatile Automated Glycoanalytical Technology for Serum Antibodies and Acute Phase Proteins: Ovarian Cancer Case Study

Affiliation:	3. NIBRT GlycoScience Group, National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Ireland, A94X099;4. Bioprocessing Technology Institute, Agency for Science, Technology and Research (ASTAR), 20 Biopolis Way, #06–01 Centros, Singapore 138668, Singapore;5. Cancer Research UK Clinical Centre at Leeds, St James'' University Hospital, Leeds LS9 7TF, UK;6. UCD School of Medicine, College of Health and Agricultural Science, University College Dublin, Belfield, Dublin 4, Ireland

Abstract:	Download : Download high-res image (109KB) Download : Download full-size image Highlights •Quantitative high-throughput glycoanalytical technology as a diagnostic tool for ovarian cancer detection. •Multiplexed approach harnessing N-glycan data for six glycoproteins from a single biological sample. •Detailed characterization of human serum N-glycans from antibodies IgG, IgM and IgA and acute phase proteins transferrin, haptoglobin and alpha-1-antitrypsin. •Structural differences in antibody and acute phase protein glycosylation for mechanistic insights.

Keywords:	glycomics glycoproteins glycosylation ovarian cancer antibodies plasma or serum analysis acute phase proteins
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